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Low-level programming in C and MIPS assembly. Memory management, pointers, bitwise operations, CPU architecture, caching, pipelining, and I/O systems.
Systems programming is no joke. You go from Python to C and MIPS assembly and its a huge jump. But Prof Blanton is great at breaking down complex topics. The labs are where you really learn - debugging segfaults at 2am builds character lol. Seriously though this class made me a much better programmer.
Tips for success
Learn GDB early. It will save your life on the later assignments.
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Challenging but students rate it highly.